In the dynamic environments of tissues, mechanical forces play a crucial role in shaping cell behavior and function. Our research aims to decode and control the mechanisms by which cells perceive, store, and respond to these mechanical cues, a process known as mechanotransduction. By integrating experiment with multiscale computational modeling, we are developing a predictive understanding of how cells and their surrounding extracellular matrix interact and adapt recursively to mechanical stimuli. Results show that mechanotransduction can be controlled to govern how cells respond to mechanical stress, with feedback loops between cells and matrix driving molecular and genetic switches. The talk will focus on our multiscale modeling approaches, linking subcellular, cellular, and tissue scale phenomena, and their application to regenerative medicine and wound healing applications.