MechE Colloquium: Acoustic manipulation: from holographic micro-tweezers to quantum analogues by Prof. Michael Baudoin, Université de Lille

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The ability to pick up and manipulate micro-objects selectively and in 3D with single-beam optical tweezers have led to tremendous developments in physics and microbiology, recognized by the Nobel prizes of S. Chu and A. Ashkin. Nevertheless, optical tweezers have stringent limitations for life science owing to (i) reported phototoxicity inducing detrimental effects on biological tissues, (ii) their inability to operate in vivo in optically opaque media, and (iii) the limited range of forces, which can be applied on biosamples (typically < 20pN). In this regard, acoustical tweezers are a prominent technology since they are non-invasive, biocompatible label-free and enable trapping forces several orders of magnitudes larger than their optical counterparts at same actuation power, hence preventing deleterious heating. Nevertheless, while the ability to collect particles and cells at the nodes or antinodes of standing waves have been reported early on, the design of selective acoustical tweezers able to pick up and manipulate particles individually and in 3D has only been demonstrated recently. In this presentation, we will show how flat, miniaturized, selective, 3D acoustical tweezers can be designed with active holograms of specific wave structures called acoustical vortices. We will demonstrate their capabilities to trap and organize cells individually with efficiency (force over power ratio) two orders of magnitude larger than their optical counterpart. Finally, we will introduce some perspectives on multiple particles assembly, 3D manipulation and ultra-high frequency acoustic tweezers. We will conclude this talk with a refreshing glimpse of how an acoustic source could surf on its own acoustic wave, paving the way toward acoustic quantum analogues.

References:
[1] M. Baudoin, J.-L. Thomas, R.A. Sahely, J.C. Gerbedoen, Z. Gong, A. Sivery, O. Bou Matar, N. Smagin, A. Vlandas, Spatially selective manipulation of cells with single beam acoustical tweezers, Nature Commun.,11: 4244 (2020)
[2] M. Baudoin & J.L. Thomas, Acoustic tweezers for particles and fluids micromanipulation, Ann. Rev. Fluid Mech, 52: 205-304 (2020)
[3] M. Baudoin, J.-C. Gerbedoen, A. Riaud, O. Bou Matar, N. Smagin, J.-L. Thomas, “Folding a focalized acoustical vortex on a flat holographic transducer: miniaturized selective acoustical tweezer,” Science Adv.: 5: eaav1967 (2019)
[4] A. Riaud, M. Baudoin, O.B. Matar, J. L Thomas and P. Brunet, On the influence of viscosity and caustics on acoustic streaming in sessile droplets: an experimental and a numerical study with a cost-effective method, J. Fluid Mech., 821: 384-420 (2017), highlighted in «Focus on Fluids»
[5] A. Roux, J.P. Martishang and M. Baudoin, Self-radiation force on a moving monopolar source, J. Fluid Mech., 952: A22 (2022)

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MechE Colloquium: Acoustic manipulation: from holographic micro-tweezers to quantum analogues by Prof. Michael Baudoin, Université de Lille

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